Pandora's Box (Charmed)

"Pandora’s box, a gift the Gods gave to Prometheus, one that contained all of the evils of the world, until Pandora unleashed it on an unsuspecting people."

- Katya (disguised as Nina) to Piper Halliwell.

Pandora's Box is an ancient magical box that contains all of the horrifying sorrows of the world and it first appeared in the eponymous episode "Little Box of Horrors" of the Charmed TV series.

It is protected by a series of powerful mortal women called "Guardians" whose sworn duty is to guard it and prevent it from being opened by demons, which is impossible for them to open in the first place, but with enough strategy, they can make the Guardian herself or a mere human open it. That title "Guardian" passes onto the box's next keeper at the death of her current predecessor as the box will move on itself only to it's new Guardian.

If it is opened, Pandora's Box will release all the Earth's sorrows and plunge the mortal world into great dismay. Only a Guardian will have enough power to put it all back into the box if she is meant to.

When Sandra, one of the Elders, explained Pandora's Box to Phoebe Halliwell, she said "it exists only to tempt, part of the Grand Design".