A.R.S.E.

Animal Research: Scientific and Experimental, also known as A.R.S.E., is a government research facility located at Lawson Park within Coniston, England and run by Dr. Boycott. It is where the scientists (known as "whitecoats" from the animals' perspective) perform torturous cosmetic research on animals, including two dogs named Rowf and Snitter.

History
After the death of his master, Snitter was sold to the A.R.S.E. by his wicked sister, where they do numerous vivisection experiments on him, causing him to have hallucinations, while they repeatedly drown Rowf to test his endurance. Dr. Boycott doesn't feel any sympathy for the animals and is usually threatening towards his subordinate, Stephen Powell. Powell wanted to get the job, because he wanted to save his sick daughter, Stephanie. A German scientist named Dr. Goodner studies the bubonic plague and plans on using it as a secret bioweapon for the Ministry of Defense. This leads to the belief that the dogs are carrying the plague after their escape when Digby Driver planned on using that information for his news articles. Harry Tyson, the institution's janitor, is in charge of feeding the dogs. He originally worked as a farmer, then a ship carrier, before becoming a janitor.

One day, Tyson forgets to latch Rowf's cage, leaving the two dogs to escape the kennel and explore the lab, while discovering other animals who were having horrible experiments done on them. A monkey startles the two dogs and accidentally break a tank containing rats near Dr. Goodner's office, which would eventually lead to the belief that they're carrying bubonic plague. They climb in an incinerator to find a way out, unaware of what it actually is. As Dr. Goodner prepares the incinerator, the two dogs make a narrow escape before the incinerator starts up, allowing them to roam the countryside.

While the two dogs try to find a master, they were forced to kill livestock in order to survive. However, the two dogs are being pursued by farmers and the whitecoats. A local fox known as "The Tod" decides to help them survive in the wild and evade the hunters who want to kill/take them back to the laboratory. An unscrupulous journalist named Digby Driver visits the lab and blackmails Dr. Goodner, so he can publish an article about the plague-carrying dogs.

In the film, Dr. Boycott hires a bounty hunter named Ackland to take down the dogs. However, he eventually falls to his death after the Tod jumps him, leaving his corpse to be scavenged by the dogs. This results in the army getting involved and the Tod is killed while drying to distract the hunters, so the two dogs can escape to the sea. They are chased by the whitecoats in a helicopter until they reach the shore. Dr. Boycott is called by the Under Secretary and overhears that he is forced to suspend his job. Meanwhile, Powell quits his job and takes a monkey with him while looking for a new career. He also plans on writing a book about the prevention of animal cruelty, which may lead to the facility getting shut down.

Victims

 * Dogs with various horrible experiments.
 * Monkeys with electrodes.
 * Rabbits in head-exposed boxes.
 * Rats given cancer before getting dissected.
 * Cats forced to wear hoods covering their eyes and ears.
 * Guinea pigs with amputated limbs.
 * Homing pigeons with damaged sensory organs and brains.
 * Mice who've been injected with the urine of potentially pregnant women.
 * Rats confined in glass boxes.

Trivia

 * The A.R.S.E. is a British slang for buttocks.