The Ultimate Annihilator was a powerful energy firearm which could cause its targets to "vanish" (disintegrate), and an object in the Marvel Comics universe. It was developed by A.I.M., who concealed the identities of the various scientists involved.
Only a statue of a dragon which played musical notes that could be decoded would lead anyone to the scientists' location. The Yellow Claw robot found the dragon statue and murdered the inventors, taking each component of the weapon.
The only surviving inventor was Po Chin Ling, who was brought to safety by S.H.I.E.L.D. The robot then modified it from a hand-held weapon into a giant cannon. The robot used it on Fury, but Fury was saved at the last moment by the Suwan robot, who teleported him to safety.
After the robot's defeat, the Ultimate Annihilator was disassembled by S.H.I.E.L.D. Some components were stored aboard the S.H.I.E.L.D. Helicarrier, and were sought by General Pollock.
- It shares the same name with the Ultimate Annihilator machine from the Sonic the Hedgehog comic book series.